5199. Collier's Wine of Quinine

5199.    Collier's Wine of Quinine. Take disulphate of quinine, 18 grains; citric acid, 15 grains ; sound orange wine, 1 bottle, or 24 fluid ounces.

5200. Chlorodyne

5200.      Chlorodyne. The composition of this well known secret remedy has excited much attention among chemists; many formulae have been published, but it is difficult to determine which of them approaches nearest to the chlorodyne of J. Collis Browne, its originator. There can be no doubt about the three important ingredients, chloroform, morphia, and hydrocyanic acid, nor can there be about oil of peppermint and molasses. The question is whether anything else exists in the compound. Hitherto, of the formulae which have been published, two - one by Dr. Ogden, the other by Mr. Squire - have attracted most attention. The difference between these lay essentially in the presence of Indian hemp and capsicum as indicated by Ogden, their absence in the formula given by Squire. But besides this, the proportion of morphia, as given by the two authorities, differed greatly. Mr. Edward Smith has recently investigated the question, and published the result in the London Pharmaceutical Journal. He puts the composition of chlorodyne as follows: Mix together 4 fluid drachms chloroform, 20 grains muriate of morphia, 2 fluid drachms rectified ether, 8 minims oil of peppermint, 4 fluid drachms diluted hydrocyanic acid, 6 fluid drachms tincture of capsicum, 1 fluid ounce acacia mixture, and add 4 fluid ounces molasses. This does not give as dark a compound as the original, because the latter contains caramel; but as this has no medicinal or other value, he omits it, making up to the required volume with the molasses. Mr. Smith thinks there is no Indian hemp, because the alcoholic extract is soluble in water; but then there is capsicum, as, after the chloroform and ether (which also give pungency to the mixture) have been distilled off, the substance left behind has a hot, peppery taste. He seems to have taken much pains with the analysis.

5201. Ogden's Chlorodyne

5201.    Ogden's Chlorodyne. The following receipt will furnish a preparation having the pharmaceutical properties of chlorodyne, according to Dr. Ogden: To 8 grains muriate of morphia and 1/2 fluid drachm water, add 20 drops perchloric acid of 25° Baumé, and heat until a clear solution is obtained; then add 1/2 fluid ounce molasses, previously warmed to render it fluid; heat the mixture and agitate well. When cold, add 11/2 fluid drachms chloroform, 12 drops hydrocyanic acid, 1 fluid drachm tincture of Indian hemp, 2 drops oil of peppermint, and 1 drop oleo-resin of capsicum. Mix thoroughly.

5202. Groves' Chlorodyne

5202.    Groves' Chlorodyne. The following is an improvement by Mr. Groves, on the receipt of Dr. Ogden. Take chloroform, 4 drachms; ether, 11/2 drachms; oil of peppermint, 8 drops; resin of Indian hemp, 16 grains; capsicum, 2 grains; macerate for 2 or 3 days, and filter. Then dissolve hydrochlorate of morphia, 16 grains, in 1 ounce of syrup; add perchloric acid and water, 1/2 drachm each, assisting tho solution by a water-bath; then, when cold, add hydrocyanic acid (Scheele's), 96 drops. Mix the solutions.