Thiosinamine, or allyl sulphocarbamide, is soluble in 3 parts of alcohol. It is decomposed by water, though this change is retarded by glycerin. Fibrolysin is the trade name for a sterile aqueous solution of a double salt of thiosinamine and sodium salicylate. It is marketed in ampules of 2.3 c.c. of solution representing 3 grains (0.2 gm.) of thiosinamine.

Thiosinamine, in dose of 1-3 grains (0.06-0.2 gm.), is administered by rectum or vagina in suppositories, or subcuta-neously in 10 per cent. freshly prepared glycerin-water suspension or in 15 per cent. alcoholic solution. It is very irritant locally.

Fibrolysin is employed subcutaneously, intramuscularly, or intravenously. The injections are given at intervals of one to three days, in some cases as many as 60 injections being given. It is less irritant locally than thiosinamine. The action of the drug is to soften scar tissue, and perhaps to promote its absorption. Starkenstein states that it favors the hydrolysis of collagen into gelatin. There are many clinical reports of its value in hypertrophied scars of the skin; in strictures of esophagus, rectum, and urethra; in fibrous ankylosis; in arthritis deformans; in sciatica; in opacities of the cornea, etc. F. Ehrlich has employed it with success to loosen the adhesions of small epigastric and umbilical hernias. Such a drug would seem to be a desideratum in therapeutics, yet it has limitations in its power to affect scar tissue, and its failures are frequent. It is contra-indicated in active inflammatory conditions, in tuberculosis where connective-tissue formation is desired, and in ulceration of the alimentary tract. It is said to be useless in corneal opacities of long standing.